UCR

Biochemistry Department



Craig V. Byus


 

Professor Byus Portrait

Craig V. Byus
Professor of Biomedical Sciences and Biochemistry



Biomedical Research
Molecular Biology


PubMed Citations
craig.byus@ucr.edu 

 

Our research has been concerned with the regulation of polyamine biosynthesis and the involvement of these events in the control of cell growth and proliferation. For some time, we have investigated the mechanisms involved in the induction of the enzyme ornithine decarboxylase (ODC), the controlling enzyme in the polyamine biosynthetic pathway. We have implicated a number of protein kinases including cAMP-dependent protein kinase and the calcium-phospholipid dependent protein kinase (protein kinase C) in the regulation of ODC activity and cell growth. We have developed some new and innovative fluorescence and biochemical procedures for studying the intracellular actions of these kinases in relation to the activation of ODC and in mediating the phosphorylation of ribosomal protein S6.

Of particular interest is the regulation of polyamine metabolism during the carcinogenic process of initiation and promotion. We have taken a nutritional approach to cancer chemoprevention based upon alterations in the substrate precursors of the polyamines to both inhibit and stimulate the growth of tumors. These dietary modifications may directly benefit the human population at risk for the development of cancer. We are also investigating several new drugs which interfere with polyamine metabolism and may offer some future benefit in the treatment of cancer and other diseases of unregulated proliferation.

Selected Publications
  • Fukumoto, G.H. and Byus, C.V. Putrescine export in Xenopus laevis occurs against a concentration gradient: Evidence for a non-diffusional export process. Biochem. Biophys. Acta 1324: 215-222 (1997).
  • Pastorian, K.E. and Byus, C.V. Tolerance to putrescine toxicity in Chinese hamster ovary cells is associated with altered uptake and export. Exp. Cell. Res. 231:284-295 (1997).
  • Fukumoto, G.H. and Byus, C.V. A kinetic characterization of putrescine and spermidine uptake and export in human erythrocytes. Biochem. Biophys. Acta 1282:48-56 (1996).
  • Tjandrawinata, R.R. and Byus, C.V. Regulation of the efflux of putrescine and cadaverine from rapidly growing cultured RAW 264 cells by extracellular putrescine. Biochem. J. 305:291-299 (1995).
  • Byus, C.V. Alterations in ornithine decarboxylase activity: A cellular response to low-energy electomagnetic field exposure. In: Summary and results of radiofrequency radiation conference, Published by U.S. Environmental Protection Agency 402-R-95-011 (1995).
  • Hawel, L. III, Tjandrawinata, R.R., Fukumoto, G.H. and Byus C.V. Biosynthesis and selective export of 1,5-diaminopentane (cadaverine) in mycoplasma-free cultured mammalian cells. J. Biol. Chem. 269:7412-7418 (1994).
  • Tjandrawinata, R.R., Hawel, L. III and Byus, C.V. Regulation of putrescine export in lipopolysaccharide IFN-Q-activated murine monocytic-leukemia RAW 264 cells. J. Immunol. 153:3039-3052 (1994).

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