UCR

Biochemistry Department



Ernest Martinez



Ernest Martinez

Ernest Martinez
Associate Professor of Biochemistry


Regulation of Chromatin and Gene Expression
Cancer Biochemistry & Molecular Biology
Biomedical Research


Martinez Research Group

PubMed Citations
ernest.martinez@ucr.edu

Awards and Honors
  • 2005-2010: CAREER Award from The National Science Foundation (USA).
  • 2003-2004: University of California Regents' Faculty Fellowship.
  • 1995-1996: Biomedical Research Fellowship, The C. H. Revson & N. & R. Winston Foundation, New York, NY.
  • 1990-1992: Postdoctoral Fellowship from The Swiss National Science Foundation.
  • 1990: Henri-A. GuĂ©nin Award for excellence in Ph.D. Thesis, University of Lausanne, Switzerland.

List of All Publications (click here)

Selected Publications
  • Xu, M., Sharma, P., Pan, S., Malik, S., Roeder, R.G., and Martinez, E. (2011) Core promoter-selective function of HMGA1 and Mediator in Initiator-dependent transcription. Genes Dev., 25, 2513-2524.

  • Wang, Y.-L., Faiola, F., Xu, M., Pan, S., and Martinez, E. (2008) Human ATAC is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. J. Biol. Chem., 283, 33808-33815. Recommended by Faculty of 1000 Biology (http://www.f1000biology.com).
  • Liu, X., Vorontchikhina, M., Wang, Y.-L., Faiola, F. and Martinez, E. (2008) STAGA recruits Mediator to the MYC oncoprotein to stimulate transcription and cell proliferation. Mol. Cell. Biol., 28, 108-121.
  • Yang, C., Bolotin, E., Jiang, T., Sladek, F. and Martinez, E. (2007) Prevalence of the Initiator over the TATA box in human and yeast genes and identification of DNA motifs enriched in human TATA-less core promoters. Gene, 389, 52-65.
  • Faiola, F., Liu, X., Lo, S.-Y., Pan, S., Zhang, K., Lymar, E., Farina, A. and Martinez , E. (2005) Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription. Mol. Cell. Biol., 25, 10220-10234.
  • Liu, X., Tesfai, J., Evrard, Y.A., Dent, S.Y.R., and Martinez, E. (2003) c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation. J. Biol. Chem., 278, 20405-20412.
  • Martinez, E., Palhan, V., Tjernberg, A., Lymar, E.S., Gamper, A.M., Kundu, T.K., Chait, B.T. and Roeder, R.G. (2001) Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. Mol. Cell. Biol., 21, 6782-6795.
  • Martinez, E., Chiang, C.-M., Ge, H. and Roeder, R.G. (1994) TATA-binding protein-associated factor(s) in TFIID function through the initiator to direct basal transcription from a TATA-less class II promoter. EMBO J., 13, 3115-3126.
  • Martinez, E., Givel, F. and Wahli, W. (1987) The estrogen-responsive element as an inducible enhancer: DNA sequence requirements and conversion to a glucocorticoid-responsive element. EMBO J., 6, 3719-3727.

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