Biochemistry Department

Ernest Martinez

Ernest Martinez

Ernest Martinez
Associate Professor of Biochemistry

Regulation of Chromatin and Gene Expression
Cancer Biochemistry & Molecular Biology
Biomedical Research

Martinez Research Group

PubMed Citations

Awards and Honors
  • 2005-2010: CAREER Award from The National Science Foundation (USA).
  • 2003-2004: University of California Regents' Faculty Fellowship.
  • 1995-1996: Biomedical Research Fellowship, The C. H. Revson & N. & R. Winston Foundation, New York, NY.
  • 1990-1992: Postdoctoral Fellowship from The Swiss National Science Foundation.
  • 1990: Henri-A. Guénin Award for excellence in Ph.D. Thesis, University of Lausanne, Switzerland.

Selected Publications
  • Wang, Y.-L., Faiola, F. and Martinez, E. (2012) Purification of Multiprotein Histone Acetyltransferase Complexes. Methods Mol. Biol., 809, 427-443.

  • Xu, M., Sharma, P., Pan, S., Malik, S., Roeder, R.G., and Martinez, E. (2011) Core promoter-selective function of HMGA1 and Mediator in Initiator-dependent transcription. Genes Dev., 25, 2513-2524.

  • Martinez, E. (2010) The NF-Y angle to the CCAAT’s tale. Cell Cycle, 9, 642-643.
  • Wang, Y.-L., Faiola, F., Xu, M., Pan, S., and Martinez, E. (2008) Human ATAC is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. J. Biol. Chem., 283, 33808-33815. Recommended by Faculty of 1000 Biology (http://www.f1000biology.com).
  • Liu, X., Vorontchikhina, M., Wang, Y.-L., Faiola, F. and Martinez, E. (2008) STAGA recruits Mediator to the MYC oncoprotein to stimulate transcription and cell proliferation. Mol. Cell. Biol., 28, 108-121.
  • Faiola, F., Wu, Y.-T., Pan, S., Zhang, K., Farina, A. and Martinez, E. (2007) Max is acetylated by p300 at several nuclear localization residues. Biochem. J., 403, 397-407.
  • Yang, C., Bolotin, E., Jiang, T., Sladek, F. and Martinez, E. (2007) Prevalence of the Initiator over the TATA box in human and yeast genes and identification of DNA motifs enriched in human TATA-less core promoters. Gene, 389, 52-65.
  • Faiola, F., Liu, X., Lo, S.-Y., Pan, S., Zhang, K., Lymar, E., Farina, A. and Martinez , E. (2005) Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription. Mol. Cell. Biol., 25, 10220-10234.
  • Zhang, K., Faiola, F. and Martinez, E. (2005) Six lysine residues on c-Myc are direct substrates for acetylation by p300. Biochem. Biophys. Res. Commun., 336, 274-280.
  • Farina, A., Faiola, F. and Martinez, E. (2004) Reconstitution of an E box-binding Myc:Max complex with recombinant full-length proteins expressed in Escherichia coli. Protein Express. Purif., 34, 215-222.
  • Liu, X., Tesfai, J., Evrard, Y.A., Dent, S.Y.R., and Martinez, E. (2003) c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation. J. Biol. Chem., 278, 20405-20412.
  • Martinez , E. (2002) Multi-protein complexes in eukaryotic gene transcription. Plant Mol. Biol., 50, 925-947 .
  • Martinez, E., Palhan, V., Tjernberg, A., Lymar, E.S., Gamper, A.M., Kundu, T.K., Chait, B.T. and Roeder, R.G. (2001) Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. Mol. Cell. Biol., 21, 6782-6795.
  • Teichman, M., Wang, Z., Martinez, E., Tjernberg, A., Zhang, D., Vollmer, F., Chait, B.T. and Roeder, R.G. (1999) Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells. Proc. Natl. Acad. Sci. USA, 96, 13720-13725.
  • Gu, W., Malik, S., Ito, M., Yuan, C.-X., Fondell, J.D., Zhang, X.L., Martinez , E., Qin, J. and Roeder, R.G. (1999) A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. Mol. Cell, 3, 97-108.
  • Martinez , E., Kundu, T.K., Fu, J. and Roeder, R.G. (1998) A human SPT3-TAFII31-GCN5-L acetylase complex distinct from TFIID. J. Biol. Chem., 273, 23781-23785.
  • Martinez , E., Ge, H., Tao, Y., Yuan, C.-X., Palhan, V. and Roeder, R.G. (1998) Novel cofactors and TFIIA mediate functional core promoter selectivity by the human TAFII150-containing TFIID complex. Mol. Cell. Biol., 18, 6571-6583.
  • Tao, Y., Guermah, M., Martinez , E., Oelgeschläger, T., Hasegawa, S., Takada, R., Yamamoto, T., Horikoshi, M. and Roeder, R.G. (1997) Specific interactions and potential functions of human TAFII100. J. Biol. Chem., 272, 6714-6721.
  • Ge, H., Martinez , E., Chiang, C.-M. and Roeder, R.G. (1996) Activator-Dependent Transcription by Mammalian RNA Polymerase II: In Vitro Reconstitution with General Transcription Factors and Cofactors. In Methods in Enzymology (Edited by Sankar Adhya), Academic Press Inc.,Vol.274, 57-71.
  • Martinez, E., Zhou, Q., L'Etoile, N., Oelgeschläger, T., Berk, A.J. and Roeder, R.G. (1995) Core promoter-specific function of a mutant transcription factor TFIID defective in TATA box-binding. Proc. Natl. Acad. Sci. USA, 92, 11864-11868.
  • Martinez, E., Chiang, C.-M., Ge, H. and Roeder, R.G. (1994) TATA-binding protein-associated factor(s) in TFIID function through the initiator to direct basal transcription from a TATA-less class II promoter. EMBO J., 13, 3115-3126.
  • Martinez, E., Lagna, G. and Roeder, R.G. (1994) Overlapping transcription by RNA polymerases II and III of the Xenopus TFIIIA gene in somatic cells. J. Biol. Chem., 269, 25692-25698.
  • Martinez, E., Dusserre, Y., Wahli, W. and Mermod, N. (1991) Synergistic transcriptional activation by CTF/NF-I and the estrogen receptor involves stabilized interactions with a limiting target factor. Mol. Cell. Biol., 11, 2937-2945.
  • Wahli, W. and Martinez, E. (1991) Superfamily of steroid nuclear receptors : positive and negative regulators of gene expression. FASEB J., 5, 2243-2249.
  • Martinez, E. and Wahli, W. (1991) Characterization of hormone response elements. In Nuclear Hormone Receptors (Edited by M. G. Parker), Academic Press Limited, New York, London, pp 125-153.
  • Martinez, E., Givel, F. and Wahli, W. (1991) A common ancestor DNA motif for invertebrate and vertebrate hormone response elements. EMBO J., 10, 263-268.
  • Martinez, E. and Wahli, W. (1989) Cooperative binding of estrogen receptor to imperfect estrogen-responsive DNA elements correlates with their synergistic hormone-dependent enhancer activity. EMBO J., 8, 3781-3791.
  • Martinez, E., Givel, F. and Wahli, W. (1987) The estrogen-responsive element as an inducible enhancer: DNA sequence requirements and conversion to a glucocorticoid-responsive element. EMBO J., 6, 3719-3727.

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