UCR

Biochemistry Department



Norman Research Group


Welcome to the Norman Research Group

Research

The purpose of my research program is the investigation of the vitamin D endocrine system and the most biologically active steroid hormones derived from the parent vitamin D, 1a,25(OH)2-vitamin D3 [1a,25(OH)2D3] and 24R,25(OH)2-vitamin D32D3]. The major thesis of our studies is that in terms of its chemical structure and mode of action, the seco-steroid, vitamin D (calciferol), is similar to other classic steroid hormones. The kidney is the endocrine gland that produces, in a physiologically regulated fashion, small amounts of 1a,25(OH)2D3 and 24R,25(OH)2D3. After systemic transport, 1a,25(OH)2D3 generates a wide array of biological responses (in over 30 target tissues) both by classical regulation of gene transcription via a nuclear receptor [VDRnuc] and rapid signal transduction pathways involving a membrane receptor [VDRmem]. The second hormone, 24R,25(OH)2D3, plays a subsidiary role in certain selected physiological circumstances, particularly in bone development and fracture-healing. [24R,25(OH)

Tony Norman's Research Interests Over the Past Four Years
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General Campus Information

University of California, Riverside
900 University Ave.
Riverside, CA 92521
Tel: (951) 827-1012

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Department Information

Department of Biochemistry
1463 Boyce Hall

Department Chair's Tel: (951) 827-3598
Fax: (951) 827-2364
Email: Biochem@ucr.edu

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