UCR

Biochemistry Department



Sato Research Group


Welcome to the Sato Research Group

Research

We study stem cell biology that bridges basic science and medical applications.

Stem cells self-renew to generate themselves while maintaining differentiation capacities. Stem cells can be classified based on their competence to give rise to distinct progenies.

The top of the hierarchy is totipotent stem cells that can generate all three germ layer-derived tissues, germ cells, and placenta. Fertilized eggs and each blastomere of preimplantation embryos until early eight cell stage retain this ability.

The next group is pluripotent stem cells whose capacity is identical to that of totipotent stem cells except the lack of the function to form placenta*. The inner cell mass (ICM) of the blastocyst, and its in vitro derivatives, embryonic stem cells (ESCs), represent this group.

The third group is multipotent stem cells whose differentiation capacity is limited within their original lineage. Adult stem cells typically belong to this class.

The last group is unipotent stem cells that can differentiate into only single cell type.

*: Human embryonic stem cells could differentiate into trophoblasts that are the founding cells of placenta but mouse embryonic stem cells can not.

Joining the Lab



More Information

General Campus Information

University of California, Riverside
900 University Ave.
Riverside, CA 92521
Tel: (951) 827-1012

Career OpportunitiesUCR Libraries
Campus StatusDirections to UCR

Department Information

Department of Biochemistry
2317 Webber Hall

Department Chair's Tel: (951) 827-3598
Fax: (951) 827-2364
Email: Biochem@ucr.edu

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