UCR

Biochemistry Department



Song Research Group


Biochemistry Department: Song Research Group

Welcome to the Song Research Group

      
song lab

Research


Our lab is interested in understanding the molecular mechanisms underlying epigenetic regulation. Genetic information in eukaryotic cells is stored in the form of chromatin, with nucleosome as repeating unit. Each nucleosome is comprised of 147-bp DNA wrapped around an octamer of histone proteins. DNA methylation and posttranslational modifications of histone proteins can significantly influence chromatin structure and function, resulting in heritable change of gene expression without changes in the genetic code, the DNA sequence. These epigenetic modifications are involved in a broad spectrum of cellular activities, including gene transcription, DNA repair, DNA replication and cell differentiation. Patterns of each epigenetic mark are dynamically regulated by a set of chromatin modifiers, whose dysregulation is linked to many human diseases, such as cancer. By using X-ray crystallography and NMR spectroscopy, combined with molecular biology and biochemistry, we aim to elucidate the molecular mechanism of key chromatin modifying enzymes, in particular their structure-function relationships and how their enzymatic activities are regulated by other epigenetic players.


Lab Members
    • Postdoctoral Researchers
    • ZhiMin Zhang
    • Zhi-Min Zhang           Email: zhimin.zhang@ucr.edu
    • XiaoFeng Tan
    • Xiao-Feng Tan          Email: xiao.feng@ucr.edu
    • Wendan
    • Wendan Ren         Email:wendan@ucr.edu
    • Graduate Students  
    • Linfeng
    • Linfeng Gao             Email: lgao010@ucr.edu
    • Boxiao
    • Boxiao Wang         Email:1992322wbx@gmail.com
    • Undergraduate Students 
    • Linhui
    • Linhui Li                 Email: lli021@ucr.edu
    • Asher Lin               Email: alin031@ucr.edu
    • Inseop Chun         Email:ichun003@ucr.edu
  • Lab Alumni
    • Matthew Harter,           BMB Graduate Student
    • Wei Zhang,                  Postdoctoral Researcher
    • Krystal Lin                    Junior Specialist


More Information

General Campus Information

University of California, Riverside
900 University Ave.
Riverside, CA 92521
Tel: (951) 827-1012

Career OpportunitiesUCR Libraries
Campus StatusDirections to UCR

Department Information

Department of Biochemistry
1463 Boyce Hall

Department Chair's Tel: (951) 827-3598
Fax: (951) 827-2364
Email: Biochem@ucr.edu

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