Biochemistry Department

Stephen R. Spindler Professor of Biochemistry Molecular Biology Biomedical Research Molecular basis of aging, Interactions between diet, health and longevity at the molecular level Spindler Research Group PubMed Citations spindler@ucrac1.ucr.edu

Awards and Honors

• Chair, Department of Biochemistry, UCR, 1998-2001
• Member, Research Planning Advisory Group, National Institute on Aging, 1998-1999
• Member, Physiological Sciences Study Section, NIH, 1992-1995

• RFA-Genetic and Molecular Basis of Aging Study Section, NIH, 1993

• Site Visit Scientific Review Committee and Study Section, NIH, 1991 (2), 1990, & 1987
• Ad Hoc Review Committee, NIH, 1990; Ad Hoc Member, Endocrinology Study Section, NIH, 1990, 1988
• NIH Postdoctoral Fellow, 1980-1981; PHS Predoctoral Trainee, 1972-1976

Selected Publications

• Dhahbi, J.M., Mote, P.L. and Spindler, S.R. Identification of potential calorie restriction mimetics by microarray profiling. Cell Aging, Submitted.
• Spindler, S.R. Rapid and reversible induction of the longevity, anticancer and genomic effects of caloric restriction. Mechanisms of Aging and Development. 31 May 2005. Epub ahead of print (2005).
• Dhahbi, J.M., Tsuchiya, T., Kim, H.J., Mote, P.L. and Spindler, S.R. Myocardial Genomic and Phenotypic Responses to Short- and Long-term Changes in Caloric Intake. Journal of Gerontology, Biological Sciences. In Press (2005).
• Tsuchiya, T., Dhahbi, J.M., Cui, X., Mote, P.L., Bartke, A. and Spindler, S.R. Additive regulation of hepatic gene expression by dwarfism and caloric restriction . Physiological Genomics, 19, 307-315 (2004); Epub 2004 Mar 23.
• Dhahbi, J.M., Kim, H.J., Mote, P.L. and Spindler, S.R. Temporal linkage between the physiologic and genomic responses to caloric restriction. Proc. Natl. Acad. Sci. USA. 101, 5524-5529 (2004); Epub 2004 Mar 25.
• Dhahbi, J.M. and Spindler, S.R. Aging of the liver. In, Biology of Aging and its Modulation, Vol. 3: Aging of Organs and Systems , Aspinall, R., ed., Kluwer Academic Publisher, Dordrecht , The Netherlands , pp. 271-291 (2003).
• Dhahbi, J.M., Mote, P.L., Cao, S.X., and Spindler, S.R. Hepatic Gene Expression Profiling of Streptozotocin-Induced Diabetes. Diabetes Technology & Therapeutics, 5, 411-420 (2003).
• Spindler, S.R. and Dhahbi, J.M. Protein Turnover, Energy Metabolism, Aging and Caloric Restriction. In, Energy Metabolism and Lifespan Determination: Advances in Cell Aging and Gerontology Vol. 14, Mattson, M.P., ed., Elsevier, Amsterdam , The Netherlands , pp. 69-86 (2003).
• Dhahbi, J.M., Cao, S.X., Mote, P.L., Wingo, J., Rowley, B.C., and Spindler, S.R. Postprandial induction of chaperone gene expression is rapid in mice. J. Nutr., 132, 31-37 (2002).
• Cao, S.X., Dhahbi, J.M., Mote, P.L., and Spindler, S.R. Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice. Proc. Natl. Acad. Sci., USA 98, 10630-10635 (2001).
  Complete data sets from this article:
  old CR vs. old Cont
  y Cont vs. old Cont
  y CR vs. old CR
  y CR vs. y Cont
• Dhahbi, J.M., Mote, P.L., Wingo, J., Rowley, B.C., Cao, S.X., Walford, R.L., and Spindler, S.R. Caloric restriction alters the feeding response of key metabolic enzyme genes. Mech. Ageing Dev., 122, 35-50 (2001).
• Dhahbi, J.M., Cao, S.X., Tillman, J.B., Mote, P.L., Madore, M.A., Walford, R.L., and Spindler, S.R. Chaperone-mediated regulation of hepatic protein secretion by caloric restriction. Biochem. Biophys. Res. Commun. 284, 335-339 (2001).
• Spindler, S.R. Caloric restriction enhances the expression of key metabolic enzymes associated with protein renewal during aging. Healthy Aging for Functional Longevity: Molecular and Cellular Interactions in Senescence, Park, S.C., Hwang, E.S., Kim, H.S., and Park, W.Y., eds. In, Annals of the New York Academy of Sciences 928, pp. 296-304 (2001).
• Weindruch, R., Keenan, K.P., Carney, J.M., Fernandes, G., Feuers, R.J., Floyd, R.A., Halter, J.B., Ramsey, J.J., Richardson, A., Roth, G.S., Spindler, S.R. Caloric restriction mimetics: Metabolic interventions. J. Gerontol. Biol. Sci. 56, 20-33 (2001).