From the UCR News Article:
"The study, published in Nature Communications, explains how protein machineries in cells are regulated to target RNA molecules for m6A modification.
Jikui Song, an associate professor of biochemistry at UC Riverside who led the study, explained ZCCHC4 controls protein synthesis and cell proliferation by introducing an m6A modification into ribosomes. ZCCHC4, he added, is overexpressed in tumors associated with hepatocellular carcinoma — the most common type of primary liver cancer.
'This is the first time anyone has determined the crystal structure of ZCCHC4,” Song said. “Our discovery can be used for structure-based drug design against cancers and lead to a better understanding of how m6A, a modification associated with numerous biological processes, is installed on ribosomal RNA.' "
Read the remainder of the article here.